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Understanding this context helps inform decisions about obtaining and using this peptide
Chemical exposure is one possible trigger, not the whole story
Molecular analyses showed that CO23RFLC had acquired a marked increased expression of the MDR1 gene encoding for an efflux pump protein mainly responsible for the drug-resistance, due to a mutation in the transcription factor gene MRR1 [16] whereas CO23RFK had a homozygous mutation (S645Y substitution) in the FSK1 gene, responsible for the synthesis of glucan [17]
The British Society of Gastroenterology (BSG) defines BO slightly differently, as an extension of salmon-coloured mucosa above the GOJ with histological confirmation of columnar mucosa
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