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Metformin: 8 Differences You Should Know About Wissam Ghusn, Alan De la Rosa, Daniel Sacoto, et al (2022)

Appropriate reasons to discuss discontinuation include achieving your weight loss goals and wanting to attempt weight maintenance without medication, experiencing intolerable side effects that don't improve with dose adjustment or supportive management, financial constraints that make continued treatment unsustainable, planning pregnancy (semaglutide is not recommended during pregnancy and should be discontinued at least two months before conception), or developing contraindications to continued use

The pharmacokinetic models for icodec and semaglutide as well as the modelling approach have been described previously [16]

Timing and pharmacokinetic effects also play significant roles