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Consequently, the metabolic pathways initiated by G proteins within GLP-1R involve cAMP activation, extracellular signal-regulated kinases 1 and 2 (ERK 1/2) and increased intracellular calcium levels (17, 19)

Within the estrogen detoxification cascade, GSTM1 has been the more extensively studied of the two for catechol estrogen quinone conjugation

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A broader investigation into alternative regulatory modalities, such as ligand-dependent cytoplasmic sequestration or post-translational modifications, could provide new insights into nuclear receptor biology and help address the challenges of deorphanization