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While these findings provide preliminary evidence of the potential benefit of semaglutide in CUD in real-world populations, further preclinical studies are warranted to understand the underlying mechanism and randomized clinical trials are needed to support its use clinically for CUD
10.3109/03602532.2011.558093 Drug Metab
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Destaques regulatrios: Diversos agonistas de GLP-1 j esto aprovados pela Anvisa , com indicao para diabetes tipo 2 Em 2023, a Anvisa aprovou a semaglutida injetvel (nome comercial Wegovy) para obesidade Algumas verses esto disponveis no SUS via Protocolos Clnicos e Diretrizes Teraputicas (PCDTs) , mas com critrios restritivos O uso para emagrecimento ainda foco de debates sobre judicializao e prescrio racional Riscos, efeitos adversos e controvrsias Apesar dos benefcios teraputicos significativos, os medicamentos base de GLP-1 no esto isentos de efeitos colaterais e desafios clnicos
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