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Andes D, et, al

1 H-fMRS spectra were acquired continuously for a 5-min baseline period and during the initial 30 min of the ketamine infusion using point resolved spectroscopy, with chemical selective suppression for water suppression and outer volume suppression with very selective suppression pulses (TR = 2,000 ms, TE = 40 ms, 8-step phase cycle, 1,040 transients out of 16 water unsuppressed transients) (Fig

Alterations in FOXO pathways have been associated in laboratory models with glucose dysregulation, lipid imbalance, and in some cases, enhanced susceptibility to metabolic disorders

a , We constructed a mutant strain that could not synthesize glutathione by knocking out, in the wild-type strain, the GSH1 gene which is essential for glutathione biosynthesis (see Mutant yeasts in the Methods section)