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Key factors influencing vomiting risk include: Dose escalation speed rapid increases in dose are associated with higher symptom rates Individual susceptibility some patients are inherently more prone to gastrointestinal side effects Concurrent medications other drugs affecting gastric motility may compound effects Dietary habits large, high-fat meals can exacerbate symptoms It is important to note that whilst mild, occasional vomiting can be an expected side effect, severe or persistent vomiting is not normal and may indicate complications requiring medical assessment