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Furthermore, efforts directed at generating combinatorial GLP-1R agonists with one or two additional peptide agonists to achieve greater weight loss (18) in a single molecule may need to consider the effect of molecular structure on the GLP-1Rdependent uptake and activity of the hybrid agonists in the CNS

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist used for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of: 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia)

doi:10.1016/j.ctim.2018.09.015

LUSC, Lung Squamous Cell Carcinoma