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The focuses of the SCALE trials were weight management and delayed onset of T2D (SCALE Obesity and Prediabetes), 61 weight management in individuals with T2D (SCALE Diabetes), 62 prevention of weight regain (SCALE Maintenance), 63 and effect of liraglutide on sleep apnea (SCALE Sleep Apnea)

Butyrate Support : Sodium Butyrate provides the short-chain fatty acid directly, supporting gut health and potentially GLP-1 production

Cellular Senescence: Inadequate glutathione accelerates cellular senescence (when cells stop dividing), contributing to aging tissues and organ dysfunction

2.1.2 Mechanisms of antimicrobial action Thionins primarily target pathogen cell membranes by interacting with negatively charged phospholipids, such as phosphatidic acid or phosphatidylserine, forming proteolipid complexes that disrupt membrane integrity through solubilization and lysis (Stec et al., 2004)