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Much like the injection, the main side effects of the oral pill are transient gastrointestinal effects, for example, nausea and constipation, which affected 74 percent of the trial participants, according to the OASIS trial, which was published in The New England Journal of Medicine
Moreover, GLP-1 changes in healthy participants and individuals with obesity were negatively correlated with anticipatory responses to food reward in the OFC after glucose intake (Heni et al., 2015)
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