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Thus, short-term activation of GH-RH receptors by GH-RH agonists in vitro leads to stimulatory effects, but chronic, long-term, persistent exposure to these ligands produces a downregulation of receptors and inhibitory effects 58,67

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Symptoms of B12 deficiency include fatigue, weakness, anemia, memory loss, mood changes, and nerve problems such as numbness or tingling in the hands and feet