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The results of paired t-tests (the Mann-Whitney U test) for VAS appetite measurements demonstrated significant differences between groups and a clear trend toward a lower level of hunger and desire to eat, a higher level of fullness and satisfaction, as well as higher satiety, in participants consuming PE with PE juice

[PubMed] [Google Scholar] 28.Tamai I, Ohashi R, Nezu Ji, Yabuuchi H, Oku A, Shimane M, Sai Y, Tsuji A

If no progress emerges after 8 weeks despite optimization, dose escalation or alternative medications (like tirzepatide or dual-compound protocols) become appropriate next steps

This leaves the door open for scientists to help delay the onset of grey hair by targeting CDK with a drug