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Myoinositol plays a crucial role in the functioning of the thyroid gland and AITD, as it regulates the organification of I and the biosynthesis of TG through the formation of hydrogen peroxide (H 2 O 2 ) in thyrocytes (57)

This meant that GLP-1RA could not only indirectly mediate M2 polarization of microglia by regulating Tregs, but also directly bind to GLP-1R on the membrane surface of microglia, completing M2 polarization through the GLP-1R/cAMP/PKA/IL-10 signaling pathway ( Recent research showed that GLP-1RA could reduce plasma TNF- levels induced by different Toll-like receptor agonists and significantly inhibit neuroinflammation (98)

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Altered Fat Distribution: The dip in oestrogen causes fat to accumulate more in the upper part of the body, particularly around organs and the waistline