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The lack of overlap between Glp1r VSM+/+ mice and Glp1r VSM/ proteomic responses strongly support a causal role for the VSMC GLP-1R in renal artery remodeling following GLP-1RA treatment

The RT-qPCR results also indicated that the inflammatory factors IL-6 and TNF- increased significantly on day 1, but there were no significant differences compared to the NC group on days 2 and 3 (Fig

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Disruption of this balance can lead to oxidative stress, a condition characterized by excess reactive oxygen species (ROS) that can damage lipids, proteins, and DNA