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One clinical trial found that participants regained about two-thirds of their previously lost weight within one year of stopping subcutaneous semaglutide.[10] Maintaining a relationship with a healthcare provider may help support long-term success by offering guidance, monitoring progress, and helping you build sustainable habits

Your body continues to respond to semaglutide even as concentrations decline, because the compound binds strongly to GLP-1 receptors on your pancreas, brain, and gut