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however, in the case of injury or disease, loss of NMNAT activity leads to NAD + depletion and NMN accumulation, which in turn activates SARM1 53,54,289

Reduced Glutathione Complex contains glutathione (GSH), a key element of the livers detoxifying process, and also the precursor for glutathione peroxidase, a major free radical scavenging enzyme

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Lipids, especially polyunsaturated fatty acids (PUFAs) in membrane phospholipids, are prime targets for ROS-induced peroxidation ( ROS also damage nucleic acids, particularly guanine bases, resulting in eight-oxoguanine formation, DNA strand breaks, and telomere shortening (Zhou et al., 2025)