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GLP-1 receptor activation slows gastric emptying, reduces appetite by acting on hypothalamic satiety centres, and stimulates glucose-dependent insulin secretion from pancreatic beta cells

Semaglutide Semaglutide supports weight loss by reducing appetite, increasing fullness, slowing stomach emptying, and improving insulin sensitivity

The choice between GLP-1 medications requires individualized assessment by a qualified healthcare provider

To mitigate any potential negative effects on methylation, additional interventions can support the methyl cycle while using folinic acid therapy: Improving SAH (S-adenosylhomocysteine) levels by reducing homocysteine through methyl donors like betaine (TMG), vitamin B6 (P5P), and methylcobalamin (B12)