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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)

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On the downside, vitamin B12 injections can be quite painful

How Fast Does a B12 Shot Work Compared to Oral Supplements Because B12 shots are administered intramuscularly and absorbed directly into the bloodstream, the nutrients bypass the slow digestive process