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It's a warning sign that intervention and lifestyle changes may be needed to prevent the development of diabetes

FDA-Approved Repatha Injection Sites Abdomen (Stomach): Inject at least 2 inches away from the navel

When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before

Managing Gastrointestinal Side Effects As a gastroenterologist, I often work with patients to manage these side effects