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Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins

Applicable Procedures Codes: 0263T, 0264T, 0265T, 0489T, 0490T, 0565T, 0566T, 0717T, 0718T, 0999T, 1000T, 1001T

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In mice single-cell RNA sequencing identified a subpopulation of GLP-1R-positive memory T-cells that was mainly composed of exhausted CD8+ T cells: functionally, stimulation of the GLP-1R on these cells was found to mediate apoptosis and anergic signals, thereby suppressing effector T-cell function and the inflammatory response ( 3.2 Intestinal mucosal barrier IELs are a heterogeneous population of T cells located among intestinal epithelial cells (IECs), where they contribute to maintaining mucosal barrier integrity (60)