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Persistent vomiting that prevents oral intake, dark amber or no urine output, rapid heart rate, confusion, fainting on standing, or heat exhaustion that doesnt improve within 3060 minutes of cooling and resting all signal that oral options have been outpaced

Treatment should only be continued if there is a beneficial metabolic response (reduction of at least 11 mmol/mol [1%] in HbA1c and weight loss of at least 3% of initial body weight at 6 months)

If a model could be affected by appetite, behaviour, autonomic tone, sexual-function pathways, or stress response, MT-II may introduce confounders