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Also, mice fed a low-fat diet with xenografts of LAPC-4 showed a decrease in tumor size along with a reduction in the IGF-I expression (138)

For instance, inhibition of MCT1 disrupts lactate homeostasis and impairs both glycolytic flux and GSH biosynthesis in MYC-driven cancer, resulting in reduced glucose uptake and depletion of ATP, NADPH and GSH (50)

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