The presence of benzyl alcohol allows the solution to remain sterile for multiple uses over time, typically up to 28 days after first puncture, unlike sterile water which must be discarded after a single use
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The investigators informed patients or their surrogates concerning the study orally and written informed consent was given before entry into the study
While NO is largely implicated in hemostatic mechanisms, in tail-amputation-models under heparin- and warfarin-administration, both the NO-synthase (NOS)-blocker, L-NAME (prothrombotic) and the NOS-substrate L-arginine (antithrombotic), were little investigated