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After that, you may shift to once-a-week injections for one to two months, and then to the maintenance phase, where you receive monthly injections

88 In recent years, studies have revealed that UA activates the TLR4-NLRP3 inflammatory complex, which is a multi-protein complex that plays a pivotal role in initiating the innate immune response to various danger signals, including MSU crystals

doi: 10.1016/j.ajpath.2015.10.001 56