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In a double-blind, placebo-controlled, cross-over study, LaRowe et al 19 examined the efficacy of NAC in 13 cocaine-dependent participants over a three-day period

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Whereas the above-mentioned studies have addressed the relationship of cognitive integrity with baseline levels of GSH, to our knowledge, it has not been explored whether GSH is modulated (showing a decrease or increase) as a consequence of cognitive effort (active engagement in a cognitive process) or sustained cognitive effort (continued engagement during a prolonged period)