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Contraindications and precautions Consider avoiding DSIP or consulting a physician if: Pregnant or breastfeeding (insufficient safety data) Taking naloxone or other opioid antagonists (may block effects) Using medications metabolized by peptidases (potential interactions) History of immune disorders (theoretical immunogenicity concern) Already using multiple sleep medications Drug interactions Because DSIP degrades via amino-peptidases in blood, medications affecting these enzymes (like the ACE inhibitor captopril) could theoretically alter DSIP metabolism

Both peptides show significant potential in enhancing wound healing, promoting collagen synthesis, and reducing inflammation in experimental models

in such settings the risk benefit ratio should be reassessed, and preservative-free preparations considered

However, calling a therapy regenerative does not prove that it regrows damaged tissue or reverses disease