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Adenylyl cyclase activation upregulates cAMP production, which exerts its effects on downstream targets via cascade signaling

Antiemetic medications, dietary modifications (small frequent meals, avoiding high-fat foods), and adequate hydration support tolerance of GLP-1 therapy

In AD mouse models, pathophysiological changes, such as anti-apoptotic effects, reduced A deposition and phosphorylated hippocampal tau, protection from synapse loss, reduced inflammatory and oxidative stress response in the cortex and hippocampus, and increased BDNF have been observed [119,120,121]

Eating smaller meals and staying hydrated can help