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GLP-1 RAs, the levels of which are increased by food intake, bind to pancreatic -cell receptors and promote insulin synthesis and secretion
1 The need for an approach offering a more holistic and comprehensive view of the body and disease is highlighted in the quote by evolutionary biologist Theodosius Dobzhansky: Nothing in biology makes sense, except in the light of evolution
Doctors use this gradual approach to help the body adjust while limiting digestive side effects
Real evidence: A 12-week study: submaximal semaglutide improved metabolic markers but showed no change in the inflammatory markers IL-6, TNF-, or PAI-1 Semaglutide dose-response studies: effects require 0.2 mg/day, and even those effects are diminished when adjusted for weight change Meta-analyses showing anti-inflammatory effects correlate with improvements in insulin resistance and weight loss, not with microdosing voodoo magic
