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Funding This work was supported in part by grands from, and grands from the National Natural Science Foundation of China (82403715, 82270585, 42125707, 82400655 and U25A201), Natural Science Foundation of Chongqing (CSTB2024NSCQ-LZX0067), Major State Basic Research Development Program of China (2022YFA1103402), and grands from the Young PhD Talent Program of Xinqiao Hospital (2023YQB016 and 2024YQB070)