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It significantly increases the risk of adverse pregnancy outcomes such as congenital anomalies, preeclampsia, abnormal fetal growth, preterm delivery and pregnancy loss [4,5,6] Preterm delivery, especially if it is very preterm or extremely preterm, and major congenital anomalies can result in children living with long term disabilities and chronic disease [7,8,9]

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For instance, disruption of circadian rhythms by repeated advances in the light-dark schedule in rodent models consistently altered expression of core clock genes such as Per2 and Bmal1, leading to impaired immune function, including reduced NK cell cytotoxicity and decreased expression of cytolytic factors like IFN, perforin, and granzyme B