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IL-6 can sensitize nociceptors directly, leading to mechanical allodynia (pain from typically non-painful stimuli) and thermal hyperalgesia (increased sensitivity to pain from heat or cold) (Sebba, 2021), while an intrathecal injection of anti-IL-6 neutralizing antibody can significantly reduce these pain-related behaviors (Zhou et al., 2016a)

It is crucial to conduct standard vitamin B6 testing in an environment with full resuscitation capabilities [13]

Lo que s est bien documentado es el efecto rebote : cuando se interrumpe el tratamiento sin haber consolidado cambios en los hbitos, gran parte del peso perdido tiende a recuperarse