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In addition to High-dose intravenous acetylcholine severe vasodilation and a profound drop in blood pressure, the high concentration of acetylcholine directly stimulates M2 muscarinic receptors in the sinoatrial (SA) node of the heart (Brown & Eccles, 1934)

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it's a biochemical alarm signaling deeper genetic and metabolic breakdowns that drive inflammation, oxidative stress, and serious health risks