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Both 1/ values were similar to the corresponding apparent catalytic efficiencies and decreased for K105X mutants by up to one or two orders of magnitude (Fig

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The cited pharmacological study has demonstrated that curdione modulates redox complexes by disrupting Keap1-Trx1 interactions while enhancing Trx1-GPX4 binding, thereby attenuating post-infarction ferroptosis through Keap1/Trx1/GPX4 axis regulation (64)

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doi: 10.1016/j.etap.2016.10.006 57 LinLYiXLiuHMengRLiSLiuXet al

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