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The temperature-dependent increase in the rate of hydrolysis of pNPB and pNPPal is likely to be extremely complex, involving contributions from the increase in k T (Arrhenius behaviour), as well as from temperature-induced reduction in viscosity, leading to increased substrate and product diffusion rates

There are also concerns about adverse events such as pancreatitis (which in rare cases have caused deaths) or optic neuropathy (which can lead to vision loss)

The FDA also said in the same warning that some compounding pharmacies claiming to sell semaglutide might instead be selling other formulations of the chemical, like semaglutide sodium and semaglutide acetate

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