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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for several indications: type 2 diabetes mellitus, chronic weight management, and more recently, to reduce the risk of major adverse cardiovascular events in adults with established cardiovascular disease and either overweight or obesity

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Chronic semaglutide treatment improves glucose tolerance, irrespective of the diet To determine the effects of chronic semaglutide treatment during juvenile malnutrition, we first characterized glucose metabolism of malnourished (LPD, 5% protein) and control (CD, 20% protein) juvenile male mice (Figure 1A)