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The concentrations of glucose and acetic acid were monitored by HPLC (LC-10AT, Shimadzu, Japan) using an Amines HPX-87H column (Bio-Rad, USA) and a refractive index detector (RID-10A, Shimadzu, Japan)

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CL ref , Q ref , V c,ref , V p,ref , F ref and k a, ref are parameter values for the reference subject profile, which is a healthy, white, non-Hispanic female aged 65 years with a body weight of 85 kg, using the abdomen as the injection site and dosed with a 1.34 mg/mL semaglutide drug product