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With its ability to easily cross the blood-brain barrier and support healthy mitochondria and energy production in the brain, in addition to reducing oxidative damage and inflammation, ALCAR is proving to be a valuable neuroprotective supplement.

On the other hand, iron-triggered lipid peroxidation activates matrix metalloproteinase-9 (MMP-9), which degrades key tight junction proteins such as ZO-1 and occludin, thereby disrupting endothelial barrier structure and increasing vascular permeability (Kim et al., 2022)

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