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The prefrontal cortex is highly sensitive to DA and even minor fluctuations can impair prefrontal cortex-dependent functions, making it particularly relevant in PTSD, as it plays a central role in suppressing fear responses, regulating stress reactivity, and enabling emotional control (Cools and D'Esposito, 2011)

Rob Newton, professor of exercise medicine Edith Cowan University, Australia, told The Sydney Morning Herald