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Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 Figure 7 Figure 8 Figure 9 4 Conclusions and perspective Inadvertently, the field of research is gradually focusing on smaller organisms, microbiomes are making their way onto the research scene, and the intestinal microbiota, mainly nonculturable bacteria, play a role in improving a healthier intestinal ecology by exerting their innate local and adaptive immune superiority