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Leptin activates TRPC channels to depolarize LepR-expressing neurons in the ventral premammillary nucleus (PMV) and POMC neurons in the ARC [143, 144]

The mice had access to their specific diet and water ad libitum

Weight loss drugs may be considered when other methods have not resulted in sufficient weight loss or when there is a need to address weight-related health concerns

Why You Need Specialist Oversight for GLP-1 Therapy Why Professional Guidance Matters GLP-1 medicines are powerful, but they may not be suitable for everyone