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In published clinical trials, both combination medications were shown to result in better glucose control than basal insulin or a GLP-1 RA alone and with the added benefit of weight loss (rather than weight gain seen with insulin alone)
In contrast to PIONEER REAL Netherlands, the next two most common categories used by people in Italian clinical practice were DPP-4 inhibitors and SGLT2 inhibitors (24.9% and 20.9%, respectively) with sulphonylureas being used by 14.6% of people [36]
However, exposure may change over time if persistent deviations in dosing conditions occur (42)
Exploratory analyses suggested that SGLT2 inhibitors might reduce risks of both AD and VD, whereas associations between GLP1 receptor agonists and AD or VD were imprecise and inconclusive
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