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The signaling through GLP-1R leads to improved glycemic control and weight management, ultimately resulting in approval of GLP-1 receptor agonist medications for the treatment of T2DM and obesity [1]

In a double-blind clinical trial in Denmark, 52 patients (mean age, 50.2 years) with verified bile acid diarrhea received either one daily subcutaneous injection of liraglutide (increasing from 0.6-1.8 mg per day over 3 weeks) or standard-of-care colesevelam (three capsules of 625 mg twice daily) for 6 weeks following one run-in week with no treatment

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Gabapentin and pregabalin in particular should not be stopped abruptly due to withdrawal risks