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Beyond the impact of endothelial damage, peritubular capillary rarefaction, pericyte detachment, nephron loss, interstitial hypoxia, and persistent inflammation, metabolic disturbances in TECsparticularly defective FAO and lipid accumulationhave been identified as key contributors to EMT and the progression of renal fibrosis through maladaptive repair mechanisms (Miguel et al., 2021)

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10.1016/j.biopha.2024.117377 4 AhmedA

In exit interviews with Mounjaro trial participants, 79% reported increased energy levels over the course of treatment