Tirzepatide (sold under the brand name Mounjaro ) is a medication that helps with weight loss by mimicking two key hormones involved in appetite regulation and blood sugar control: GLP-1 (Glucagon-Like Peptide-1) receptor agonist This hormone slows down stomach emptying, reduces appetite, and increases the feeling of fullness after eating
the medication withdrawing from your body) is the weight regain
The beneficial effects on appetite regulation typically persist while initial discomfort resolves, though individual experiences vary
Overall, when administering GLP-1RA plus SGLT2i combination therapy, it is important to adopt an individualized approach to therapy taking into account individual preferences, costs and coverage, AE profile, consideration of kidney function and glucose-lowering efficacy, desire for weight loss, and comorbidities such as frailty [6, 22, 24]