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However, the multi-component nature of TCM makes the identification of bioactive components and the clarification of synergistic or antagonistic relationships among them particularly complex, which remains a significant challenge in TCM

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EZH2 represses IGFBP1 (a decidualization marker) by increasing H3K27Me3 at the IGFBP1 promoter, impairing decidualization, while EZH2 knockdown or conditional deletion in mouse ESCs rescues decidualization defects and improves fertility ( Chromatin remodeling factors also play a pivotal role

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