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They may include symptoms beyond breakouts

A possible implication of MCT9 in some cancer types was reported: the transporter seems to be a good diagnostic target to distinguish benign from malignant adrenocortical tumors (Fernandez-Ranvier et al., 2008)

Therefore, the effective concentration of PAG required for CSE inhibition may vary substantially across tissues with different intracellular cysteine levels (Yadav et al., 2019)