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doi: 10.3389/fimmu.2020.571731 10 XieQHeYZhouDJiangYDengYLiR

For patients without a gallbladder who may already experience altered bowel habitsparticularly looser stools or more frequent bowel movements due to continuous bile flowthese medication-related effects could potentially be more noticeable

Conclusion 4-5: The lack of validated mechanistic biomarkers, beyond amyloid and tau, that can confirm that a pathway has been engaged by an intervention is compounded by the lack of markers that can act as a surrogate endpoint for assessing the efficacy of an intervention and limit the capacity of clinical trials to rapidly evaluate interventions

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