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for use in dietary supplements, and that the ingredient is not intended for use in sterile drugs

It interacts with the hypothalamus , a part of the brain responsible for controlling appetite

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Sitagliptin and Metformin Coadministration In a two-day study in healthy subjects, sitagliptin alone increased active GLP-1 concentrations, whereas metformin alone increased active and total GLP-1 concentrations to similar extents