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Liraglutide was the first GLP-1 receptor analogue approved for the management of obesity, thus starting the new era of gastrointestinal peptide agonist pharmacotherapy for the treatment of both diabetes and obesity

SCFAs promotes intestinal barrier integrity, pancreatic -cell proliferation and insulin biosynthesis, where enteric dysbiosis reduces SCFAs synthesis (Tan et al., 2014

The starting dose is 0.25 mg once weekly for four weeks, followed by 0.5 mg for four weeks, then 1 mg for four weeks, then 1.7 mg for four weeks, and finally 2.4 mg once weekly as the maintenance dose

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