It matters mostly because injectable GLP-1 therapy is a weekly or twice-weekly routine, so injection-site comfort has a real effect on confidence and long-term adherence
The post-discontinuation phase remains the least investigated, although extension studies consistently show that weight regain occurs rapidly, with patients regaining up to two-thirds of the lost weight within one year after withdrawal ( As the field evolves, questions remain about whether the future of obesity and diabetes management will prioritize pharmacotherapy, lifestyle, or a hybrid approach, especially given the challenges of long-term adherence and the broader health impacts of lifestyle change ( This narrative review synthesizes current evidence on GLP-1RAs, including both conventional single-agent therapies and dual GIP/GLP-1 receptor agonists, versus exercise, their combined effects, and the implications for future clinical and public health priorities
There's a lot to be said for know thyself, said ONeil
Whats more, your bladder has to be able to contract to expel the urine into the urethra