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Another randomized controlled trial by Zhang et al., 2025 was assessed as low risk of bias, with adequate randomization, outcome completeness, and statistical analysis

Consider over-the-counter options if needed Occasionally, mild stool softeners, osmotic laxatives, or fiber supplements may help relieve constipation

Furthermore, transcripts that regulate gene expression to promote cell maturity, such as aristaless related homeobox ( ARX ) and Iroquois homeobox 2 ( IRX2 ) (5052), were increased in a step-wise fashion across -1 to -4 cells (Figure 3D)